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  • Phospho-FOXO3-S253 pAb

Phospho-FOXO3-S253 pAb

Cat.#: 166653

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Product Information

  • Product Name
    Phospho-FOXO3-S253 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-FOXO3-S253
  • Tested applications
    WB, IHC, IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    FOXO3 antibody; AF6q21 antibody; FKHRL1 antibody; FKHRL1P2 antibody; FOXO2 antibody; FOXO3A antibody; forkhead box O3 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A phospho specific peptide corresponding to residues surrounding S253 of human FOXO3
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:1000
    IHC 1:50 - 1:100
    IF 1:50 - 1:200
  • Validations

    Western blot - Phospho-FOXO3-S253 pAb

    Western blot - Phospho-FOXO3-S253 pAb

    Western blot analysis of extracts of Untreated and treated 293 cell line, using Phospho-FOXO3-S253 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.

  • Background
    Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"