Polyclonal antibody to Phospho-FLNA-S2152
FLNA antibody; ABP-280 antibody; ABPX antibody; CSBS antibody; CVD1 antibody; FLN antibody; FLN-A antibody; FLN1 antibody; FMD antibody; MNS antibody; NHBP antibody; OPD antibody; OPD1 antibody; OPD2 antibody; XLVD antibody; XMVD antibody; filamin-A antibody
Antigen: A synthetic phosphorylated peptide around S2152 of human FLNA (NP_001104026.1).
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Store at -20℃. Avoid freeze / thaw cycles.
WB 1:500 - 1:2000
Western blot - Phospho-FLNA-S2152 pAb
Western blot analysis of extracts of HeLa and C6 cells, using Phospho-FLNA-S2152 antibody at 1:1000 dilution. Hela cell lysate were treated by CIP (20ul CIP for each 400ul cell lysate) at 37u2103 for 1 hour .C6 cell lysate were treated by CIP (20ul CIP for each 400ul cell lysate) at 37u2103 for 1 hour .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.Detection: ECL Enhanced Kit .Exposure time: 30s.
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity).
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