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  • Phospho-CFL1-Y88/CFL2-Y88 pAb

Phospho-CFL1-Y88/CFL2-Y88 pAb

Cat.#: 166405

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Product Information

  • Product Name
    Phospho-CFL1-Y88/CFL2-Y88 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-CFL1-Y88/CFL2-Y88
  • Tested applications
    WB, IHC
  • Species reactivity
    Human, Mouse
  • Alternative names
    antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A phospho specific peptide corresponding to residues surrounding Y88 of human CFL1/CFL2
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:1000
    IHC 1:50 - 1:100
  • Validations

    Western blot - Phospho-CFL1-Y88/CFL2-Y88 pAb

    Western blot - Phospho-CFL1-Y88/CFL2-Y88 pAb

    Western blot analysis of extracts from mouse heart tissue, using Phospho-CFL1-Y88/CFL2-Y88 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.

  • Background
    Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"