NovoPro
Cart 2
  • Phospho-CDKN1A-T145 pAb

Phospho-CDKN1A-T145 pAb

Cat.#: 166402

Special Price 232.3 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Phospho-CDKN1A-T145 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-CDKN1A-T145
  • Tested applications
    IHC
  • Species reactivity
    Human
  • Alternative names
    CDKN1A antibody; CAP20 antibody; CDKN1 antibody; CIP1 antibody; MDA-6 antibody; P21 antibody; SDI1 antibody; WAF1 antibody; p21CIP1 antibody; cyclin-dependent kinase inhibitor 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A phospho specific peptide corresponding to residues surrounding T145 of human CDKN1A
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    IHC 1:50 - 1:100
  • Validations

    Immunohistochemistry - Phospho-CDKN1A-T145 pAb

    Immunohistochemistry - Phospho-CDKN1A-T145 pAb

    Immunohistochemistry of paraffin-embedded human breast carcinoma using Phospho-CDKN1A-T145 antibody .

  • Background
    May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"