Polyclonal antibody to Phospho-CDKN1A-T145
CDKN1A antibody; CAP20 antibody; CDKN1 antibody; CIP1 antibody; MDA-6 antibody; P21 antibody; SDI1 antibody; WAF1 antibody; p21CIP1 antibody; cyclin-dependent kinase inhibitor 1 antibody
Antigen: A phospho specific peptide corresponding to residues surrounding T145 of human CDKN1A
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Store at -20℃. Avoid freeze / thaw cycles.
IHC 1:50 - 1:100
Immunohistochemistry - Phospho-CDKN1A-T145 pAb
Immunohistochemistry of paraffin-embedded human breast carcinoma using Phospho-CDKN1A-T145 antibody .
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding.
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