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  • Phospho-CAV1-Y14 pAb
  • Phospho-CAV1-Y14 pAb

Phospho-CAV1-Y14 pAb

Cat.#: 166397

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Product Information

  • Product Name
    Phospho-CAV1-Y14 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-CAV1-Y14
  • Tested applications
    WB, IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    CAV1 antibody; BSCL3 antibody; CGL3 antibody; LCCNS antibody; MSTP085 antibody; PPH3 antibody; VIP21 antibody; caveolin-1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A phospho specific peptide corresponding to residues surrounding Y14 of human CAV1
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IF 1:100 - 1:200
  • Validations

    Western blot - Phospho-CAV1-Y14 pAb

    Western blot - Phospho-CAV1-Y14 pAb

    Western blot analysis of extracts from 3T3 cells using Phospho-CAV1-Y14 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.

    Immunofluorescence - Phospho-CAV1-Y14 pAb

    Immunofluorescence - Phospho-CAV1-Y14 pAb

    Immunofluorescence analysis of methanol-fixed HeLa cells using Phospho-CAV1-Y14 antibody .

  • Background
    May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"