NovoPro
Cart 2
  • Mouse Abl2 Antibody (C-term)

Mouse Abl2 Antibody (C-term)

Cat.#: 134850

Size:

Special Price 177.4 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Mouse Abl2 Antibody (C-term)
  • Documents
  • Description
    Purified Rabbit Polyclonal Antibody (Pab)
  • Tested applications
    WB, ELISA
  • Species reactivity
    Mouse
  • Alternative names
    Abelson tyrosine-protein kinase 2 antibody; Abelson murine leukemia viral oncogene homolog 2 antibody; Abelson-related gene protein antibody; Tyrosine-protein kinase ARG antibody; Abl2 {ECO:0000312|EMBL:AAY860391 antibody; ECO:0000312|MGI:MGI:87860} antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This Mouse Abl2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1011-1044 amino acids from the C-terminal region of Mouse Abl2.
  • Clonality
    polyclonal
  • Storage instructions
    Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
  • Applications
    WB: 1:2000
  • Validations

    Anti-Abl2 Antibody (C-term)at 1:2000 dilution + mouse brain lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 128 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

    Anti-Abl2 Antibody (C-term)at 1:2000 dilution + mouse brain lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 128 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

  • Background
    Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL or DOK1. Required for adhesion-dependent phosphorylation of ARHGAP35 which promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"