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  • IKB alpha (IKBA) Antibody

IKB alpha (IKBA) Antibody

Cat.#: 134896

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Special Price 372.6 USD

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Product Information

  • Product Name
    IKB alpha (IKBA) Antibody
  • Documents
  • Description
    Purified Rabbit Polyclonal Antibody (Pab)
  • Tested applications
    WB, ELISA
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    IKBA antibody; MAD3 antibody; NFKBI antibody; NF-kappa-B inhibitor alpha antibody; I-kappa-B-alpha antibody; IkB-alpha antibody; IkappaBalpha antibody; Major histocompatibility complex enhancer-binding protein MAD3 antibody; NFKBIA antibody; IKBA antibody; MAD3 antibody; NFKBI antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This IKB alpha (IKBA) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human IKB alpha (IKBA).
  • Clonality
    Polyclonal
  • Formulation
    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
  • Storage instructions
    Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
  • Applications
    WB: 1:2000
  • Validations

    All lanes : Anti-Sumo-site. NFkB Antibody at 1:2000 dilution Lane 1: Daudi whole cell lysate Lane 2: Hela whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: K562 whole cell lysate Lane 5: NIH/3T3 whole cell lysate Lane 6: PC-12 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 36 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

    All lanes : Anti-Sumo-site. NFkB Antibody at 1:2000 dilution Lane 1: Daudi whole cell lysate Lane 2: Hela whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: K562 whole cell lysate Lane 5: NIH/3T3 whole cell lysate Lane 6: PC-12 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 36 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

  • Background
    Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"