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  • Human S100B Recombinant protein (GST tag)

Human S100B Recombinant protein (GST tag)

Cat.#: 512370

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Product Information

  • Product Name
    Human S100B Recombinant protein (GST tag)
  • Documents
  • Description
    S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. S100B exerts both intracellular and extracellular functions. Intracellular S100B acts as a stimulator of cell proliferation and migration and an inhibitor of apoptosis and differentiation, which might have important implications during brain, cartilage and skeletal muscle development and repair, activation of astrocytes in the course of brain damage and neurodegenerative processes, and of cardiomyocyte remodeling after infarction, as well as in melanomagenesis and gliomagenesis. As an extracellular factor, S100B engages RAGE (receptor for advanced glycation end products) in a variety of cell types with different outcomes (i.e. beneficial or detrimental, pro-proliferative or pro-differentiative) depending on the concentration attained by the protein, the cell type and the microenvironment. This calcium binding astrocyte-specific cytokine, presents a marker of astrocytic activation and reflects CNS injury. The excellent sensitivity of S100B has enabled it to confirm the existence of subtle brain injury in patients with mild head trauma, strokes, and after successful resuscitation from cardiopulmonary arrest. Recent findings provide evidence, that S100B may decrease neuronal injury and/or contribute to repair following traumatic brain injury (TBI). Hence, S100B, far from being a negative determinant of outcome, as suggested previously in the human TBI and ischemia literature, is of potential therapeutic value that could improve outcome in patients who sustain various forms of acute brain damage.
  • Protein name
    Protein S100-B
  • Protein short names
    S100-B; NEF; S100B; S100BETA; AI850290; S100; BPB; MGC74317
  • Uniprot ID
    P04271
  • Gene Name
    S100B
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    1-92 aa encoded by BC001766 was inserted into PGEX-4T vector
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human S100B SDS-PAGE

    Recombinant human S100B SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"