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  • Human PTHLH Recombinant protein (His tag)

Human PTHLH Recombinant protein (His tag)

Cat.#: 511666

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Product Information

  • Product Name
    Human PTHLH Recombinant protein (His tag)
  • Documents
  • Description
    Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1. {, PubMed:20637541}.; Osteostatin is a potent inhibitor of osteoclastic bone resorption. {PubMed:20637541}.
  • Protein name
    Parathyroid hormone-related protein
  • Protein short names
    PTHRP
  • Uniprot ID
    P12272
  • Gene Name
    PTHLH; PTHRP
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    1-175 aa encoded by NM_002820 was inserted into PET30a vector
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human PTHLH SDS-PAGE

    Recombinant human PTHLH SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"