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Product Name
Human PKM Recombinant protein (His tag)
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Description
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
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Protein name
Pyruvate kinase PKM
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Protein short names
CTHBP; THBP1; AL024370; AL024424; PK-2; HEL-S-30; MGC3932; OIP3; AA414905; TCB; PKM2; PKM; PK3; PK-3
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Uniprot ID
P14618
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Gene Name
PKM; OIP3; PK2; PK3; PKM2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
1-531 aa encoded by NM_002654 was inserted into PET28a vector
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human PKM SDS-PAGE
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