• Human KDR Recombinant protein (His tag)

Human KDR Recombinant protein (His tag)

Cat.#: 509211

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Product Information

  • Product Name
    Human KDR Recombinant protein (His tag)
  • Documents
  • Description
    VEGFR2, also called as KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the inhibition of VEGFR2 activity and its downstream signaling are important targets for the treatment of diseases involving angiogenesis. VEGFR2 transduces the major signals for angiogenesis via its strong tyrosine kinase activity. However, unlike other representative tyrosine kinase receptors, VEGFR2 does not use the Ras pathway as a major downstream signaling but rather uses the phospholipase C-protein kinase C pathway to signal mitogen-activated protein (MAP)-kinase activation and DNA synthesis. VEGFR2 is a direct and major signal transducer for pathological angiogenesis, including cancer and diabetic retinopathy, in cooperation with many other signaling partners; thus, VEGFR2 and its downstream signaling appear to be critical targets for the suppression of these diseases. VEGF and VEGFR2-mediated survival signaling is critical to endothelial cell survival, maintenance of the vasculature and alveolar structure and regeneration of lung tissue. Reduced VEGF and VEGFR2 expression in emphysematous lungs has been linked to increased endothelial cell death and vascular regression.
  • Protein name
    Receptor protein-tyrosine kinase
  • Protein short names
    KDR; LY73; VEGFR2; VEGFR; CD309; 6130401C07; SVEGFR-2; FLK-1; KRD-1; FLK1; VEGFR-2
  • Uniprot ID
    P35968
  • Gene Name
    KDR; hCG_31572
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    1158-1345 aa encoded by NM_002253 was inserted into PET28a vector
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human KDR SDS-PAGE

    Recombinant human KDR SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"