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  • Human CDK4 Recombinant protein (His tag)

Human CDK4 Recombinant protein (His tag)

Cat.#: 506430

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Special Price 294.7 USD

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Product Information

  • Product Name
    Human CDK4 Recombinant protein (His tag)
  • Documents
  • Description
    CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. CDK4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to Cdk6 overexpression in lymphoma, leukemia and melanoma.
  • Protein name
    Cyclin-dependent kinase 4, isoform CRA_a
  • Protein short names
    CRK3; MGC14458; PSK-J3; CDK4; CMM3
  • Uniprot ID
    P11802
  • Gene Name
    CDK4; hCG_40151
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    1-303 aa encoded by BC010153 was inserted into PET28a vector
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human CDK4(Full length) SDS-PAGE

    Recombinant human CDK4(Full length) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"