FER (Phospho-Tyr402) Antibody

FER (Phospho-Tyr402) Antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Purified Rabbit Polyclonal Antibody (Pab)

WB, IHC

Human

TYK3 antibody; Tyrosine-protein kinase Fer antibody; Feline encephalitis virus-related kinase FER antibody; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer antibody; Proto-oncogene c-Fer antibody; Tyrosine kinase 3 antibody; p94-Fer antibody; FER antibody; TYK3 antibody

Rabbit IgG

Polyclonal

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.

WB: 1:1000, IHC: 1:50~100

Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.