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Gene name
caspase 8
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Organism
Human
- Entrez Gene ID
-
Gene Symbol
CASP8
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Gene Type
protein coding
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Also Known as
CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
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Encoded Protein Alias
caspase-8; FADD-homologous ICE/CED-3-like protease; FADD-like ICE; ICE-like apoptotic protease 5; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MORT1-associated ced-3 homolog; apoptotic cysteine protease; apoptotic protease Mch-5; caspase 8, apoptosis-related cysteine protease
Accession NO.: XM_005246893
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Product Name
CASP8(XM_005246893) Human cDNA/ORF Clone
- Accession NO.
-
Transcript Name
PREDICTED: Homo sapiens caspase 8 (CASP8), transcript variant X12, mRNA.
-
Synonyms
-
ORF length
885
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siRNA
GAUAAUCAACGACUAUGAAtt
GAUCAGAAUUGAGGUCUUUtt
GAUACUGUCUGAUCAUCAAtt
- DataSheet:
- FAQs:
Accession NO.: XM_005246885
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Product Name
CASP8(XM_005246885) Human cDNA/ORF Clone
- Accession NO.
-
Transcript Name
PREDICTED: Homo sapiens caspase 8 (CASP8), transcript variant X1, mRNA.
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Synonyms
-
ORF length
1572
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siRNA
GAUAAUCAACGACUAUGAAtt
GAUCAGAAUUGAGGUCUUUtt
GAUACUGUCUGAUCAUCAAtt
- DataSheet:
- FAQs:
Accession NO.: NM_033358
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Product Name
CASP8(NM_033358) Human cDNA/ORF Clone
- Accession NO.
-
Transcript Name
Homo sapiens caspase 8 (CASP8), transcript variant E, mRNA.
- Synonyms
-
ORF length
708
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Annotation
This variant (E), also known as Beta-1, has multiple differences, one of which causes a frameshift, compared to variant G. It encodes isoform E, which is shorter than isoform G.
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siRNA
GAUAAUCAACGACUAUGAAtt
GAUCAGAAUUGAGGUCUUUtt
GAUACUGUCUGAUCAUCAAtt
- DataSheet:
- FAQs:
Accession NO.: NM_033355
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Product Name
CASP8(NM_033355) Human cDNA/ORF Clone
- Accession NO.
-
Transcript Name
Homo sapiens caspase 8 (CASP8), transcript variant B, mRNA.
- Synonyms
-
ORF length
1440
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Annotation
This variant (B) includes different segments in its 5' UTR and lacks a 5' coding region segment, compared to variant G. This results in translation at a downstream start codon, and the encoded protein (isoform B) has a shorter N-terminus when it is compared to isoform G.
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siRNA
GAUAAUCAACGACUAUGAAtt
GAUCAGAAUUGAGGUCUUUtt
GAUACUGUCUGAUCAUCAAtt
- DataSheet:
- DataSheet:
- DataSheet:
- DataSheet:
- DataSheet:
- DataSheet:
- FAQs:
Accession NO.: XM_005246895
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Product Name
CASP8(XM_005246895) Human cDNA/ORF Clone
- Accession NO.
-
Transcript Name
PREDICTED: Homo sapiens caspase 8 (CASP8), transcript variant X15, mRNA.
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Synonyms
-
ORF length
840
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siRNA
GAUAAUCAACGACUAUGAAtt
GAUCAGAAUUGAGGUCUUUtt
GAUACUGUCUGAUCAUCAAtt
- DataSheet:
- FAQs:
Accession NO.: XM_011511969
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Product Name
CASP8(XM_011511969) Human cDNA/ORF Clone
- Accession NO.
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Transcript Name
PREDICTED: Homo sapiens caspase 8 (CASP8), transcript variant X11, mRNA.
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Synonyms
-
ORF length
1005
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siRNA
GAUAAUCAACGACUAUGAAtt
GAUACUGUCUGAUCAUCAAtt
- DataSheet:
- FAQs:
Accession NO.: NM_033356
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Product Name
CASP8(NM_033356) Human cDNA/ORF Clone
- Accession NO.
-
Transcript Name
Homo sapiens caspase 8 (CASP8), transcript variant F, mRNA.
- Synonyms
-
ORF length
1395
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Annotation
This variant (F) includes different segments in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant G. Variants C and F both encode isoform C, which is shorter than isoform G. Isoform C has also been labelled as Alpha-2 or MCH5-beta.
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siRNA
GAUAAUCAACGACUAUGAAtt
GAUCAGAAUUGAGGUCUUUtt
GAUACUGUCUGAUCAUCAAtt
- DataSheet:
- FAQs:
Accession NO.: NM_001080125
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Product Name
CASP8(NM_001080125) Human cDNA/ORF Clone
- Accession NO.
-
Transcript Name
Homo sapiens caspase 8 (CASP8), transcript variant G, mRNA.
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Synonyms
-
ORF length
1617
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Annotation
This variant (G), also known as procaspase-8L or 8L, encodes the longest protein (isoform G).
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siRNA
GAUAAUCAACGACUAUGAAtt
GAUCAGAAUUGAGGUCUUUtt
GAUACUGUCUGAUCAUCAAtt
- DataSheet:
- FAQs:
Accession NO.: NM_001228
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Product Name
CASP8(NM_001228) Human cDNA/ORF Clone
- Accession NO.
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Transcript Name
Homo sapiens caspase 8 (CASP8), transcript variant A, mRNA.
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Synonyms
-
ORF length
1491
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Annotation
This variant (A), also known as Alpha-4, has multiple differences in the 5' UTR and coding region, compared to variant G. It encodes isoform A which is shorter than isoform G.
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siRNA
GAUAAUCAACGACUAUGAAtt
GAUCAGAAUUGAGGUCUUUtt
GAUACUGUCUGAUCAUCAAtt
- DataSheet:
- FAQs:
Accession NO.: XM_005246894
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Product Name
CASP8(XM_005246894) Human cDNA/ORF Clone
- Accession NO.
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Transcript Name
PREDICTED: Homo sapiens caspase 8 (CASP8), transcript variant X14, mRNA.
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Synonyms
-
ORF length
843
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siRNA
GAUAAUCAACGACUAUGAAtt
GAUCAGAAUUGAGGUCUUUtt
GAUACUGUCUGAUCAUCAAtt
- DataSheet:
- FAQs:
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Vector Name
pEXP-C-EGFP
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primers
T7: TAATACGACTCACTATAGGG
BGH: TAGAAGGCACAGTCGAGG -
Vector Length
6703
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Vector Type
Mammalian Expression Vector
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Promoter
CMV
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Antibiotic Resistance
Kanamycin
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Selection Marker
Hygromycin
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Protein Tag
GFPSpark
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Description
All of the pEXP vectors are designed for high-level stable and transient expression in mammalian hosts. High-level stable and non-replicative transient expression can be carried out in most mammalian cells. The vectors contain the following elements:
• Human enhanced cytomegalovirus immediate-early (CMV) promoter for high-level expression in a wide range of mammalian cells.
• Hygromycin resistance gene for selection of mammalian cell lines.
• A Kozak consensus sequence to enhance mammalian expression.
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Vector Name
pEXP-C-FLAG
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primers
T7: TAATACGACTCACTATAGGG
BGH: TAGAAGGCACAGTCGAGG -
Vector Length
6013
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Vector Type
Mammalian Expression Vector
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Promoter
CMV
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Antibiotic Resistance
Kanamycin
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Selection Marker
Hygromycin
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Protein Tag
FLAG
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Description
All of the pEXP vectors are designed for high-level stable and transient expression in mammalian hosts. High-level stable and non-replicative transient expression can be carried out in most mammalian cells. The vectors contain the following elements:
• Human enhanced cytomegalovirus immediate-early (CMV) promoter for high-level expression in a wide range of mammalian cells.
• Hygromycin resistance gene for selection of mammalian cell lines.
• A Kozak consensus sequence to enhance mammalian expression.
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Vector Name
pEXP-C-mOrange2
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primers
T7: TAATACGACTCACTATAGGG
BGH: TAGAAGGCACAGTCGAGG -
Vector Length
6662
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Vector Type
Mammalian Expression Vector
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Promoter
CMV
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Antibiotic Resistance
Kanamycin
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Selection Marker
Hygromycin
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Protein Tag
OFPSpark
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Description
All of the pEXP vectors are designed for high-level stable and transient expression in mammalian hosts. High-level stable and non-replicative transient expression can be carried out in most mammalian cells. The vectors contain the following elements:
• Human enhanced cytomegalovirus immediate-early (CMV) promoter for high-level expression in a wide range of mammalian cells.
• Hygromycin resistance gene for selection of mammalian cell lines.
• A Kozak consensus sequence to enhance mammalian expression.
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Vector Name
pEXP-N-FLAG
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primers
T7: TAATACGACTCACTATAGGG
BGH: TAGAAGGCACAGTCGAGG -
Vector Length
6013
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Vector Type
Mammalian Expression Vector
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Promoter
CMV
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Antibiotic Resistance
Kanamycin
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Selection Marker
Hygromycin
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Protein Tag
FLAG
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Description
All of the pEXP vectors are designed for high-level stable and transient expression in mammalian hosts. High-level stable and non-replicative transient expression can be carried out in most mammalian cells. The vectors contain the following elements:
• Human enhanced cytomegalovirus immediate-early (CMV) promoter for high-level expression in a wide range of mammalian cells.
• Hygromycin resistance gene for selection of mammalian cell lines.
• A Kozak consensus sequence to enhance mammalian expression.
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Vector Name
pOTENT-1
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primers
pOT-F: TAATAGTAATCAATTACGGG
pOT-R: CCTCTACAAATGTGGTATGGC -
Vector Length
7510
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Vector Type
Mammalian Expression Vector
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Promoter
CMV
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Antibiotic Resistance
Kanamycin
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Selection Marker
Neomycin
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Protein Tag
FLAG, 6 His
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Description
ORFs cloned in this vector will be expressed in mammalian cells as a tagged protein with the C-terminal FLAG-6 His tags.
Such clones are the best for detection and purification of the transgene using anti-FLAG or anti-His antibodies.
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Vector Name
pUC18c
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primers
M13 fwd: GTAAAACGACGGCCAGT
M13 rev: CAGGAAACAGCTATGAC -
Vector Length
2693
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Vector Type
Cloning Vector
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Promoter
lac
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Antibiotic Resistance
Ampicillin
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Selection Marker
-
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Protein Tag
None
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Description
pMD18-T Vector is a high-efficiency TA cloning vector constructed from pUC18, of which the initial multiple cloning sites (MCS) were destroyed. Thus the cDNA should be amplified by PCR with primers containing a restriction site for subclone. Competent cells appropriate for pUC18 are also appropriated for this Vector, e.g. JM109, DH5α, TOP10. The pMD18-T Simple Vector is 2.6kb in size. Selection of the plasmid in E. coli is conferred by the ampicillin resistance gene. The coding sequence was inserted by TA cloning at site 425.
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Vector Name
pcDNA3.1-3xFlag
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primers
T7: TAATACGACTCACTATAGGG
BGH: TAGAAGGCACAGTCGAGG -
Vector Length
5508
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Vector Type
Mammalian Expression Vector
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Promoter
CMV
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Antibiotic Resistance
Ampicillin
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Selection Marker
Neomycin
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Protein Tag
Flag
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Description
Mammalian vector for expressing C-terminal 3xFlag tagged proteins.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"