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  • Anti-Transferrin Receptor/TFRC/CD71 antibody

Anti-Transferrin Receptor/TFRC/CD71 antibody

Cat.#: 105355

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Product Information

  • Product Name
    Anti-Transferrin Receptor/TFRC/CD71 antibody
  • Documents
  • Description
    Mouse monoclonal to Transferrin Receptor/TFRC/CD71
  • Tested applications
  • Species reactivity
    Human Transferrin Receptor / TFRC / CD71
  • Alternative names
    Tr antibody; Mtvr-1 antibody; TFR antibody; TFR antibody; TR antibody; Transferrin Receptor antibody; Transferrin Receptor antibody; Trfr antibody; T9 antibody; TFR antibody; CD71 antibody; TFR1 antibody; TRFR antibody; TFR antibody; p90 antibody; CD71 antibody; TFR1 antibody; Trfr antibody; Mtvr1 antibody; Mtvr-1 antibody; AI195355 antibody; AI426448 antibody; AU015758 antibody; 2610028K12Rik antibody; E430033M20Rik antibody; P90 antibody; 2610028K12Rik antibody; AI195355 antibody; AI426448 antibody; AU015758 antibody; TR antibody; CD71 antibody; CD71 antibody; E430033M20Rik antibody; Mtvr1 antibody; p90 antibody; TFR1 antibody; TFR1 antibody; Tfrc antibody; TFRC antibody; TRFR antibody
  • Immunogen
  • Isotype
    Mouse IgG1
  • Preparation
    This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Transferrin Receptor / TFRC / CD71 (rh Transferrin Receptor / TFRC / CD71; NP_003225.2; Cys89-Phe760). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    FCM: 0.5-2 μg/Test

  • Validations

    Transferrin Receptor / TFRC / CD71 Antibody, Mouse MAb, Flow Cytometry

    Transferrin Receptor / TFRC / CD71 Antibody, Mouse MAb, Flow Cytometry

    Flow cytometric analysis of Human TFRC(CD71) expression on U937 cells. Cells were stained with purified anti-Human TFRC(CD71), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

  • Background
    Mouse transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.
  • References
    • Douabin-Gicquel V., et al., 2001,Hum. Genet. 109:393-401.
    • Ryschich,E. et al., 2004,Eur J Cancer. 40 (9):1418-22.
    • Tosoni D., et al., 2005, Cell 123:875-888.
    • Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.