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  • Anti-Transferrin Receptor/TFRC/CD71 antibody

Anti-Transferrin Receptor/TFRC/CD71 antibody

Cat.#: 104193

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Product Information

  • Product Name
    Anti-Transferrin Receptor/TFRC/CD71 antibody
  • Documents
  • Description
    Rabbit monoclonal to Transferrin Receptor/TFRC/CD71
  • Tested applications
  • Species reactivity
    Human Transferrin Receptor / TFRC / CD71
  • Alternative names
    Tr antibody; Mtvr-1 antibody; TFR antibody; TFR antibody; TR antibody; Transferrin Receptor antibody; Transferrin Receptor antibody; Trfr antibody; T9 antibody; TFR antibody; CD71 antibody; TFR1 antibody; TRFR antibody; TFR antibody; p90 antibody; CD71 antibody; TFR1 antibody; Trfr antibody; Mtvr1 antibody; Mtvr-1 antibody; AI195355 antibody; AI426448 antibody; AU015758 antibody; 2610028K12Rik antibody; E430033M20Rik antibody; P90 antibody; 2610028K12Rik antibody; AI195355 antibody; AI426448 antibody; AU015758 antibody; TR antibody; CD71 antibody; CD71 antibody; E430033M20Rik antibody; Mtvr1 antibody; p90 antibody; TFR1 antibody; TFR1 antibody; Tfrc antibody; TFRC antibody; TRFR antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human Transferrin Receptor / TFRC / CD71 (rh Transferrin Receptor / TFRC / CD71; NP_003225.2; Cys89-Phe 760) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
  • Clonality
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
  • Validations

    Transferrin Receptor / TFRC / CD71 Antibody (FITC), Rabbit MAb, Flow cytometric

    Transferrin Receptor / TFRC / CD71 Antibody (FITC), Rabbit MAb, Flow cytometric

    Expression of TFRC (CD71) by stimulated human peripheral blood mononuclear cells (PBMC). Human PBMC were stimulated with immobilized anti-human CD3 antibody (1 μg/ml for coating culture wells; BD Cat. No. 555329), in the presence of recombinant human IL-2 (200 IU/ml final concentration) for 3 days.

  • Background
    Mouse transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.
  • References
    • Douabin-Gicquel V., et al., 2001,Hum. Genet. 109:393-401.
    • Ryschich,E. et al., 2004,Eur J Cancer. 40 (9):1418-22.
    • Tosoni D., et al., 2005, Cell 123:875-888.
    • Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.