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  • Anti-TNFRSF14 antibody

Anti-TNFRSF14 antibody

Cat.#: 141649

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Product Information

  • Product Name
    Anti-TNFRSF14 antibody
  • Documents
  • Description
    Rabbit Monoclonal to Human TNFRSF14
  • Tested applications
    FCM
  • Species reactivity
    Human HVEM/TNFRSF14/CD270
  • Alternative names
    ATAR antibody; Atar antibody; HveA antibody; HVEA antibody; Hvem antibody; HVEM antibody; LIGHTR antibody; MGC123498 antibody; MGC123499 antibody; RP24-89N4.1 antibody; RP3-395M20.6 antibody; Tnfrs14 antibody; Tnfrsf14 antibody; TNFRSF14 antibody; TR2 antibody; ATAR antibody; HVEA antibody; HVEM antibody; CD270 antibody; LIGHTR antibody; Atar antibody; HveA antibody; Hvem antibody; Tnfrs14 antibody; TR2 antibody; CD270 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human HVEM/TNFRSF14/CD270 .
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    FCM: 0.5-2 μg/test

  • Validations

    Human HVEM/TNFRSF14/CD270 Flow Cytometry (FC) 15376

    Human HVEM/TNFRSF14/CD270 Flow Cytometry (FC) 15376

  • Background
    Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor superfamily. It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM is also involved in the unique inhibitory signaling pathway for T cells through activating tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) in B and T lymphocyte attenuator (BTLA). HVEM provides a stimulatory signal following engagement with LIGHT (TNFSF14) on T cells. In contrast, it can also provide an inhibitory signal to T cells when it binds the B and T lymphocyte attenuator (BTLA), a ligand member of the Immunoglobulin (Ig) superfamily. Thus, HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.

    Immune Checkpoint
    Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies
    Immune Checkpoint Proteins
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"