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  • Anti-FGFR4 antibody

Anti-FGFR4 antibody

Cat.#: 142399

Special Price 145.0 USD

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Product Information

  • Product Name
    Anti-FGFR4 antibody
  • Documents
  • Description
    Rabbit Polyclonal to Rhesus FGFR4
  • Tested applications
    ELISA
  • Species reactivity
    Rhesus FGFR4 / CD334
  • Alternative names
    TKF antibody; JTK2 antibody; CD334 antibody; Fgfr-4 antibody; CD334 antibody; FGFR4 antibody; Fgfr4 antibody; Fgfr-4 antibody; JTK2 antibody; MGC20292 antibody; TKF antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Rhesus FGFR4 / CD334 . Total IgG was purified by Protein A affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.5-1 μg/ml

    This antibody can be used at 0.5-1 μg/ml with the appropriate secondary reagents to detect Rhesus FGFR4 / CD334.

  • Validations
  • Background
    Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"