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  • Anti-DIABLO antibody

Anti-DIABLO antibody

Cat.#: 142198

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Special Price 193.4 USD

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Product Information

  • Product Name
    Anti-DIABLO antibody
  • Documents
  • Description
    Rabbit Monoclonal to Human DIABLO
  • Tested applications
    IP
  • Species reactivity
    Human SMAC / Diablo
  • Alternative names
    SMAC antibody; DFNA64 antibody; Smac antibody; AU040403 antibody; 0610041G12Rik antibody; 1700006L01Rik antibody; 0610041G12Rik antibody; 1700006L01Rik antibody; AU040403 antibody; Diablo antibody; DIABLO antibody; DIABLO-S antibody; FLJ10537 antibody; FLJ25049 antibody; hCG_1782202 antibody; Smac antibody; SMAC antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human SMAC / Diablo .
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IP: 0.5-2 μg/mg of lysate

  • Validations

    SMAC / Diablo Antibody, Rabbit MAb, Immunoprecipitation

    SMAC / Diablo Antibody, Rabbit MAb, Immunoprecipitation

  • Background
    Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (Diablo) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. The current knowlege about structure and function of Smac/Diablo during programmed cell death, both in mitochondrial and receptor pathways are presented. It has been shown that Diablo mainly interacts with IAPs in the cytochrome c/Apaf-1/caspase-9 pathway, and promotes apoptosis. Diablo is released from the mitochondria into the cytosol occurring downstream of cytochrome c release in response to apoptotic stimuli such as irradiation, DNA damage or cytotoxic drugs. In the cytosol, Smac/Diablo interacts and antagonizes inhibitors of apoptosis proteins (IAPs), thus allowing the activation of caspases and apoptosis. This activity has prompted the synthesis of peptidomimetics that could potentially be used in cancer therapy. The role of Smac/DIABLO in colorectal carcinogenesis is ill defined. Data continues to accumulate to suggest that decreased levels of Smac/DIABLO may be important in chemoradiation-resistance to apoptosis in advanced colon cancer.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"